By M. A. Christine Pratt (auth.), Grant N. Pierce, Volodymyr I. Mizin, Alexander Omelchenko (eds.)
The chance for publicity to harmful radiation, poisonous chemical substances within the setting and opposed organic brokers has elevated exponentially at the present time. The extra common and speedier commute that we event this present day additionally escalates the chance of contraction and transmission of doubtless lethal infections. This has created a really genuine and escalating threat for accidents and deaths. this is often accentuated within the army and clinical employees that's extra often uncovered to radiological, chemical, and organic brokers of their basic operating atmosphere. realizing the mechanisms wherein those poisonous brokers inflict harm to bodies is vital to arrange us for those demanding situations. a lot of the wear and tear is inflicted in the course of the new release of loose radicals and non-radical oxidants which then act via oxidative mechanisms to harm the physique. This quantity will speak about the wear because of those radiological, chemical, and organic environmental stressors, the mechanisms during which the wear and tear can take place and the unconventional options that may be used to minimize the harm inflicted by means of those poisonous compounds. utilizing uncomplicated and scientific learn methods, the contents of this publication speak about new principles for the improvement of bioactive items and environmental ways to reduce or negate the organic harm inflicted via those noxious compounds.
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Extra resources for Advanced Bioactive Compounds Countering the Effects of Radiological, Chemical and Biological Agents: Strategies to Counter Biological Damage
These radiation mitigating chemicals include kinase inhibitor (EX-Rad), inhibitors of inflammation such as (Minozac) and ethyl pyruvate (EP), mitochondrial targeting agents, such as (JP4-039), cytochrome c – cardiolipin peroxidase inhibitor, triphenyl-phosphonium (TPEY-Tempo), hemigramicidin S-conjugated 4-amoni-2,2,6,6-tetramethyl-piperidineN-oxyl (hemi-GS-TEMPO). The radiation mitigating biologics include agonists of toll-like receptor (TLR) CBLB502, a recombinant protein derivative of Salmonella enterica flagellin, and a synthetic lipopeptide CBLB600; a thrombopoietin agonist, Alxn4100TPO (4100TPO); 2 Antioxidants as a Bio-shield Against Radiological Weapons 21 cytokines, IL-12, synthokine SC-55494, a synthetic cytokine, IL-11, IL-1and TNF-α and hepatocyte growth factor; a somatostatin analog SOM230 (pasireotide) and SOM230-LAR, a long-acting release form of SOM230; and BIO 300.
Weiss JF, Landauer MR (2000) Radioprotection by antioxidants. Ann N Y Acad Sci 899:44–60 57. Wu W, Abraham L, Ogony J et al (2008) Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells. Life Sci 82:1122–1130 58. Xiao M, Li XH, Fu D et al (2010) Radioprotective and therapeutic effects of δ-tocotrienol in mouse bone marrow hematopoietic tissue (in vivo study). In: 56th annual meeting of Radiation Research Society, Maui, 25–29 Sept 2010, p 129a Chapter 3 Sensing Mechanisms of the Low-Power Infrared Radiation Irina Katina, Igor Yachnev, Vera Plakhova, Tatyana Shelykh, Ilya Rogachevsky, Svetlana Podzorova, and Boris V.
Thus, BC and vitamin A have, in part, different biological functions. Therefore, both BC and vitamin A should be added to a multiple micronutrient preparation. The gradient of oxygen pressure varies within the cells. Some antioxidants, such as vitamin E, are more effective as quenchers of free radicals in reduced oxygen pressure, whereas BC and vitamin A are more effective in higher atmospheric pressures. Vitamin C is necessary to protect cellular components in aqueous environments, whereas carotenoids, vitamins A and vitamin E protect cellular components in lipid environments.