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Andreoli and Carpenter's Cecil Essentials of Medicine (8th by Thomas E. Andreoli, Ivor J. Benjamin, Robert C. Griggs,

By Thomas E. Andreoli, Ivor J. Benjamin, Robert C. Griggs, Edward J. Wing

Scholars, citizens, and teachers swear via Andreoli and Carpenter’s Cecil necessities of medication since it provides simply the correct quantity of knowledge, simply the precise approach. Edited through the past due Thomas E. Andreoli, MD in addition to Ivor Benjamin, MD, Robert C. Griggs, MD, and Edward J. Wing, MD, it makes a speciality of center ideas and the way they follow to sufferer care, overlaying every thing you want to be aware of to prevail on a scientific rotation or residency. Masterful enhancing and a undemanding full-color layout make soaking up and keeping details as easy as attainable, and pupil seek advice on-line entry deals handy, versatile connection with the total contents of the e-book plus extra scientific photographs and radiologic photos, video clips demonstrating methods, audio recordings of middle and lung sounds, and extra.

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Extra info for Andreoli and Carpenter's Cecil Essentials of Medicine (8th Edition)

Sample text

Deoxyribonucleic Acid and the Genome All organisms possess a scheme to transmit the essential information containing the genetic make-up of the species through successive generations. In human cells, 23 pairs of chromosomes are present, each pair of which contains a 2 unique sequence and therefore unique genetic information. In the human genome, about 6 × 109 nucleotides, or 3 × 109 pairs of nucleotides, associate in the double helix. All the specificity of DNA is determined by the base sequence, and this sequence is stored in complementary form in the double-helical structure, which facilitates correction of sequence errors and provides a mechanistic basis for replication of the information during cell division.

Epigenetics refers to heritable changes in gene expression without changes in the DNA sequence. Such examples include DNA methylation, gene silencing, chromatin remodeling, and X-chromosome inactivation. This form of inheritance involves the alterations in gene function without changes in DNA sequence. Chemical marking of DNA methylation is both cell specific and developmentally regulated. Methylation of the 5′ CpG dinucleotide by specific methyl transferases, which occurs in 70% of the mammalian genome, is another mechanism of gene regulation.

In human cells, 23 pairs of chromosomes are present, each pair of which contains a 2 unique sequence and therefore unique genetic information. In the human genome, about 6 × 109 nucleotides, or 3 × 109 pairs of nucleotides, associate in the double helix. All the specificity of DNA is determined by the base sequence, and this sequence is stored in complementary form in the double-helical structure, which facilitates correction of sequence errors and provides a mechanistic basis for replication of the information during cell division.

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